Ischemic heart disease is the leading single cause of death and is also the leading cause of death among circulatory diseases in the Republic of Croatia. For this reason, this work aimed to collect the latest data on Ischemic heart disease mortality and to calculate epidemiological indicators, such as standardized rates, based on which the obtained results would be comparable. Data sources are the Croatian Institute of Public Health, the Croatian Bureau of Statistics, and the Croatian Chamber of Commerce. Two main variables used in this paper were: (i) Number of deaths from Ischemic heart disease grouped by sex, age groups, years, and counties; (ii) Population. Using these two variables mortality measures were later calculated. In this paper, these measures were calculated and presented: (i) Crude and standardized mortality rates from Ischemic heart disease for Croatia and all its counties in the period from 2014 to 2019; (ii) Percentage changes for Croatia and its four regions; (iii) Percentage of premature deaths; (iv) Male to female ratio; (v) Pearson product-moment correlation coefficient (r) as a measure of the strength of a linear association between the Index of Economic Strength and the standardized mortality rate for both sexes. Mortality from Ischemic heart disease in Croatia is in the expected decline with a maintained regional difference. More women die from Ischemic heart disease compared to the number of men, but male to female ratio is higher >1 throughout Croatia. Men, too, are more likely to die younger. The development of an individual county is weakly negatively correlated with the mortality rate from Ischemic heart disease and does not represent a variable that significantly determines the variability of mortality from Ischemic heart disease.