prikaz prve stranice dokumenta Adrenergic hyperactivity: a missing link between multiple sclerosis and cardiovascular comorbidities?
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Adrenergic hyperactivity: a missing link between multiple sclerosis and cardiovascular comorbidities?
Acta Neurologica Belgica, 120 (2020), 3; 581-587. https://doi.org/10.1007/s13760-018-1051-4
Habek, Mario; Mutak, Tomislav; Nevajdić, Bojana; Pucić, Dunja; Crnošija, Luka; Krbot Skorić, Magdalena

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Habek, M., Mutak, T., Nevajdić, B., Pucić, D., Crnošija, L. i Krbot Skorić, M. (2020). Adrenergic hyperactivity: a missing link between multiple sclerosis and cardiovascular comorbidities?. Acta Neurologica Belgica, 120. (3), 581-587. doi: 10.1007/s13760-018-1051-4

Habek, Mario, et al. "Adrenergic hyperactivity: a missing link between multiple sclerosis and cardiovascular comorbidities?." Acta Neurologica Belgica, vol. 120, br. 3, 2020, str. 581-587. https://doi.org/10.1007/s13760-018-1051-4

Habek, Mario, Tomislav Mutak, Bojana Nevajdić, Dunja Pucić, Luka Crnošija i Magdalena Krbot Skorić. "Adrenergic hyperactivity: a missing link between multiple sclerosis and cardiovascular comorbidities?." Acta Neurologica Belgica 120, br. 3 (2020): 581-587. https://doi.org/10.1007/s13760-018-1051-4

Habek, M., et al. (2020) 'Adrenergic hyperactivity: a missing link between multiple sclerosis and cardiovascular comorbidities?', Acta Neurologica Belgica, 120(3), str. 581-587. doi: 10.1007/s13760-018-1051-4

Habek M, Mutak T, Nevajdić B, Pucić D, Crnošija L, Krbot Skorić M. Adrenergic hyperactivity: a missing link between multiple sclerosis and cardiovascular comorbidities?. Acta Neurologica Belgica [Internet]. 06.2020. [pristupljeno 17.04.2024.];120(3):581-587. doi: 10.1007/s13760-018-1051-4

M. Habek, T. Mutak, B. Nevajdić, D. Pucić, L. Crnošija i M. Krbot Skorić, "Adrenergic hyperactivity: a missing link between multiple sclerosis and cardiovascular comorbidities?", Acta Neurologica Belgica, vol. 120, br. 3, str. 581-587, Lipanj 2020. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:377935. [Citirano: 17.04.2024.]

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Naslov (engleski)Adrenergic hyperactivity: a missing link between multiple sclerosis and cardiovascular comorbidities?
AutorMario Habek
AutorTomislav Mutak
AutorBojana Nevajdić
AutorDunja Pucić
AutorLuka Crnošija
AutorMagdalena Krbot Skorić
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA NEUROLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Neurologija
Sažetak (engleski)
The aim of the study is to investigate differences in non-standard adrenergic baroreflex sensitivity (BRS) indices in patients with different phenotypes of multiple sclerosis (pwMS) and healthy controls (HC). Retrospective analysis of types of systolic blood pressure (BP) curves during Valsalva maneuver (VM) [balanced (BAR), augmented (AAR) and suppressed (SAR) autonomic responses] and adrenergic baroreflex sensitivity (BRSa) measured with BRSa1, α-BRSa and β-BRSa in patients with clinically isolated syndrome (CIS), relapsing remitting multiple sclerosis (RRMS), progressive multiple sclerosis (PMS) and HC. We also investigated correlations between BRSa1, α-BRSa, β-BRSa and resting catecholamine levels. pwMS had higher α-BRSa compared to HC (p = 0.02). There was no difference in BRSa1, s and β-BRSa between patients with CIS, RRMS and PMS. There was no association between pwMS and HC, and the type of sBP curve [χ2 = 4.332, p = 0.114]. pwMS and BAR or AAR had higher supine systolic and diastolic BP compared to pwMS and SAR. There was a significant correlation between α-BRSa and upright systolic BP (rp =0.194, p = 0.017), α-BRSa and norepinephrine (rs =0.228, p = 0.021), and BRSa1 and epinephrine (rs = 0.226, p = 0.040). pwMS and HC exhibit different alpha-adrenergic response to Valsalva maneuver. These results may explain the connection between MS and increased cardiovascular risk.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaActa Neurologica Belgica
Brojčani podacivol. 120, br. 3, str. 581-587
p-ISSN0300-9009
e-ISSN2240-2993
DOIhttps://doi.org/10.1007/s13760-018-1051-4
URN:NBNurn:nbn:hr:105:377935
Datum objave publikacije2020-06
URL dokumentahttp://link.springer.com/10.1007/s13760-018-1051-4
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Datum isteka embarga: 2021-06-30
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2021-01-14 09:36:00