Introduction and aim of the study: Due to the non-selective action of cytostatics during the reception of chemotherapy, side effects occur that can affect the treatment and quality of life of patients. The aim of this study was to examine the association between changes in taste perception and quality of life in patients receiving chemotherapy. Subjects and methods: A cross-sectional study was conducted on a sample of subjects (N = 258) in the Outpatient Clinic, Department of Oncology, the University Hospital Centre in Zagreb. The respondents completed three questionnaires. Sociodemographic data and course of treatment questionnaire, quality of life questionnaire for oncology patients (EORTC QLQ-C30) and Chemotherapy-induced taste alteration scale (CiTAS). Data analysis was performed in SPSS 20. Results: The study included 102 respondents (73.5 % women) who agreed to participate in the study (coverage 39.5 %), average age 55.10 years. The most common primary site for cancer were breast (64.7 %). As a type of chemotherapy, most subjects received chemotherapy with Paclitaxel (45.1 %). The results on the chemotherapy-induced taste alteration scale were moderately negatively correlated with the result on the general health and health-related quality of life scale. The greatest association between changes in taste perception was with lower cognitive functioning (r = -0.47; p < 0.001). The highest correlations between the overall CiTAS score were with the symptoms of nausea and vomiting (r = 0.51; p < 0.001) and with loss of appetite (r = 0.49; p < 0.001). No differences were found on any dimension of the CiTAS scale with respect to the type of chemotherapy patients receive, nor the association with age. Conclusion: The results of the study showed that subjects with pronounced changes in taste perception have lower assessments of general health/quality of life. Changes in taste perception were not associated with type of chemotherapy and age. The results of the study indicate the need for additional education of patients on side effects that may occur as a result of receiving chemotherapy. The protocol and instruments used in this study may serve for appropriate interventions in patients receiving chemotherapy.