prikaz prve stranice dokumenta Methylation pattern of Caveolin-1 in prostate cancer as potential cfDNA biomarker
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Methylation pattern of Caveolin-1 in prostate cancer as potential cfDNA biomarker
Bosnian Journal of Basic Medical Sciences, 23 (2022), 1; 176-186. https://doi.org/10.17305/bjbms.2022.7497
Škara, Lucija; Vodopić, Tonći; Pezelj, Ivan; Abramović, Irena; Vrhovec, Borna; Vrtarić, Alen; Sinčić, Nino; Tomas, Davor; Bulimbašić, Stela; Kuliš, Tomislav; Ulamec, Monika

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Škara, L., Vodopić, T., Pezelj, I., Abramović, I., Vrhovec, B., Vrtarić, A. ... Ulamec, M. (2022). Methylation pattern of Caveolin-1 in prostate cancer as potential cfDNA biomarker. Bosnian Journal of Basic Medical Sciences, 23. (1), 176-186. doi: 10.17305/bjbms.2022.7497

Škara, Lucija, et al. "Methylation pattern of Caveolin-1 in prostate cancer as potential cfDNA biomarker." Bosnian Journal of Basic Medical Sciences, vol. 23, br. 1, 2022, str. 176-186. https://doi.org/10.17305/bjbms.2022.7497

Škara, Lucija, Tonći Vodopić, Ivan Pezelj, Irena Abramović, Borna Vrhovec, Alen Vrtarić, Nino Sinčić, et al. "Methylation pattern of Caveolin-1 in prostate cancer as potential cfDNA biomarker." Bosnian Journal of Basic Medical Sciences 23, br. 1 (2022): 176-186. https://doi.org/10.17305/bjbms.2022.7497

Škara, L., et al. (2022) 'Methylation pattern of Caveolin-1 in prostate cancer as potential cfDNA biomarker', Bosnian Journal of Basic Medical Sciences, 23(1), str. 176-186. doi: 10.17305/bjbms.2022.7497

Škara L, Vodopić T, Pezelj I, Abramović I, Vrhovec B, Vrtarić A, i sur.. Methylation pattern of Caveolin-1 in prostate cancer as potential cfDNA biomarker. Bosnian Journal of Basic Medical Sciences [Internet]. 01.02.2022. [pristupljeno 11.04.2024.];23(1):176-186. doi: 10.17305/bjbms.2022.7497

L. Škara, et al., "Methylation pattern of Caveolin-1 in prostate cancer as potential cfDNA biomarker", Bosnian Journal of Basic Medical Sciences, vol. 23, br. 1, str. 176-186, Veljača 2022. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:191297. [Citirano: 11.04.2024.]

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Podaci o radu
Naslov (engleski)Methylation pattern of Caveolin-1 in prostate cancer as potential cfDNA biomarker
AutorLucija Škara
AutorTonći Vodopić
AutorIvan Pezelj
AutorIrena Abramović
AutorBorna Vrhovec
AutorAlen Vrtarić
AutorNino Sinčić
AutorDavor Tomas
AutorStela Bulimbašić
AutorTomislav Kuliš
AutorMonika Ulamec
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA MEDICINSKU BIOLOGIJU)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA PATOLOGIJU)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA UROLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Patologija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Urologija
Sažetak (engleski)
High prevalence and mortality of prostate cancer (PCa) are well known global health issues. Novel biomarkers for better identifying patients with PCa are the subject of extensive research. Prostate specific antigen (PSA) shows low specificity in screening and diagnostics, leading to unnecessary biopsies and health costs. Eighty patients with PCa and benign prostate hyperplasia (BPH) were included in the study. We analyzed CAV1 gene expression and methylation in tissue. CAV1 cfDNA methylation from blood and seminal plasma was accessed as a potential PCa biomarker. Although methylation in blood plasma did not differ between PCa and BPH patients, methylation in seminal plasma showed better PCa biomarker performances than tPSA (AUC 0.63 vs. AUC 0.52). Discrimination of BPH and Gleason grade group 1 PCa patients from patients with higher Gleason grade groups revealed very good performance as well (AUC 0.72). CAV1 methylation is useful biomarker with potential for further seminal plasma cfDNA research, but its diagnostic accuracy should be improved, as well as general knowledge about cfDNA in seminal plasma.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaBosnian Journal of Basic Medical Sciences
Brojčani podacivol. 23, br. 1, str. 176-186
p-ISSN1512-8601
e-ISSN1840-4812
DOIhttps://doi.org/10.17305/bjbms.2022.7497
URN:NBNurn:nbn:hr:105:191297
Datum objave publikacije2022-02-01
URL dokumentahttps://www.bjbms.org/ojs/index.php/bjbms/article/view/7497
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2023-03-01 16:36:11