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AICAr, a Widely Used AMPK Activator with Important AMPK-Independent Effects: A Systematic Review
Cells, 10 (2021), 5; 1095. https://doi.org/10.3390/cells10051095
Višnjić, Dora; Lalić, Hrvoje; Dembitz, Vilma; Tomić, Barbara; Smoljo, Tomislav

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Višnjić, D., Lalić, H., Dembitz, V., Tomić, B. i Smoljo, T. (2021). AICAr, a Widely Used AMPK Activator with Important AMPK-Independent Effects: A Systematic Review. Cells, 10. (5). doi: 10.3390/cells10051095

Višnjić, Dora, et al. "AICAr, a Widely Used AMPK Activator with Important AMPK-Independent Effects: A Systematic Review." Cells, vol. 10, br. 5, 2021. https://doi.org/10.3390/cells10051095

Višnjić, Dora, Hrvoje Lalić, Vilma Dembitz, Barbara Tomić i Tomislav Smoljo. "AICAr, a Widely Used AMPK Activator with Important AMPK-Independent Effects: A Systematic Review." Cells 10, br. 5 (2021). https://doi.org/10.3390/cells10051095

Višnjić, D., et al. (2021) 'AICAr, a Widely Used AMPK Activator with Important AMPK-Independent Effects: A Systematic Review', Cells, 10(5). doi: 10.3390/cells10051095

Višnjić D, Lalić H, Dembitz V, Tomić B, Smoljo T. AICAr, a Widely Used AMPK Activator with Important AMPK-Independent Effects: A Systematic Review. Cells [Internet]. 04.05.2021. [pristupljeno 11.04.2024.];10(5). doi: 10.3390/cells10051095

D. Višnjić, H. Lalić, V. Dembitz, B. Tomić i T. Smoljo, "AICAr, a Widely Used AMPK Activator with Important AMPK-Independent Effects: A Systematic Review", Cells, vol. 10, br. 5, Svibanj 2021. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:140315. [Citirano: 11.04.2024.]

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Podaci o radu
Naslov (engleski)AICAr, a Widely Used AMPK Activator with Important AMPK-Independent Effects: A Systematic Review
AutorDora Višnjić
AutorHrvoje Lalić
AutorVilma Dembitz
AutorBarbara Tomić
AutorTomislav Smoljo
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA FIZIOLOGIJU I IMUNOLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Fiziologija čovjeka
Sažetak (engleski)
5-Aminoimidazole-4-carboxamide ribonucleoside (AICAr) has been one of the most commonly used pharmacological modulators of AMPK activity. The majority of early studies on the role of AMPK, both in the physiological regulation of metabolism and in cancer pathogenesis, were based solely on the use of AICAr as an AMPK-activator. Even with more complex models of AMPK downregulation and knockout being introduced, AICAr remained a regular starting point for many studies focusing on AMPK biology. However, there is an increasing number of studies showing that numerous AICAr effects, previously attributed to AMPK activation, are in fact AMPK-independent. This review aims to give an overview of the present knowledge on AMPK-dependent and AMPK-independent effects of AICAr on metabolism, hypoxia, exercise, nucleotide synthesis, and cancer, calling for caution in the interpretation of AICAr-based studies in the context of understanding AMPK signaling pathway.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaCells
Brojčani podacivol. 10, br. 5, 1095
e-ISSN2073-4409
DOIhttps://doi.org/10.3390/cells10051095
URN:NBNurn:nbn:hr:105:140315
Datum objave publikacije2021-05-04
URL dokumentahttps://www.mdpi.com/2073-4409/10/5/1095
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2021-11-08 10:22:38