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Genomic Instability of the APC Gene found in Glioblastoma
U: Genome Research Advances / Bellini, P. Alberto (ur.). Nova Science Publishers, Inc., 2007. str. 219-235. urn:nbn:hr:105:120092
Pećina-Šlaus, Nives; Beroš, Vili; Nikuševa-Martić, Tamara; Bulić-Jakuš, Floriana

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Pećina Šlaus, N., Beroš, V., Nikuševa Martić, T. i Bulić Jakuš, F. (2007). Genomic Instability of the APC Gene found in Glioblastoma. U P. A. Bellini, (Ur.), Genome Research Advances (str. 219-235). Nova Science Publishers, Inc.. Preuzeto s https://urn.nsk.hr/urn:nbn:hr:105:120092

Pećina Šlaus, Nives, et al. "Genomic Instability of the APC Gene found in Glioblastoma." Genome Research Advances, Ur. P. Alberto Bellini, Nova Science Publishers, Inc., 2007, str. 219-235. https://urn.nsk.hr/urn:nbn:hr:105:120092

Pećina Šlaus, Nives, Vili Beroš, Tamara Nikuševa Martić i Floriana Bulić Jakuš. "Genomic Instability of the APC Gene found in Glioblastoma." U Genome Research Advances, ur. P. Alberto Bellini, 219-235. Nova Science Publishers, Inc., 2007. https://urn.nsk.hr/urn:nbn:hr:105:120092

Pećina Šlaus, N., et al. (2007) 'Genomic Instability of the APC Gene found in Glioblastoma' u Bellini, P. A. (ur.) Genome Research Advances Nova Science Publishers, Inc., str. 219-235. Preuzeto s: https://urn.nsk.hr/urn:nbn:hr:105:120092 (Datum pristupa: 16.04.2024.)

Pećina Šlaus N, Beroš V, Nikuševa Martić T, Bulić Jakuš F. Genomic Instability of the APC Gene found in Glioblastoma. U: P. A. Bellini, ur. Genome Research Advances. Nova Science Publishers, Inc.; 2007. Str. 219-235. [pristupljeno 16.04.2024.] Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:120092

N. Pećina Šlaus, V. Beroš, T. Nikuševa Martić i F. Bulić Jakuš, "Genomic Instability of the APC Gene found in Glioblastoma", Genome Research Advances, P. A. Bellini, Ur. Nova Science Publishers, Inc., 2007, str. 219-235. [Online] Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:120092

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Naslov (engleski)Genomic Instability of the APC Gene found in Glioblastoma
AutorNives Pećina-Šlaus
AutorVili Beroš
AutorTamara Nikuševa-Martić
AutorFloriana Bulić-Jakuš
UrednikP. Alberto Bellini
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA MEDICINSKU BIOLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
The etiology and pathogenesis of tumors of the central nervous system are still inadequately explained. This study analyses tumor suppressor gene— adenomatous polyposis coli (APC) in 28 patients with glioblastoma, the most aggressive form of glial tumors. APC protein has a structural role in adherens junctions, but also plays a signaling role as a negative regulator of the wnt pathway. Our interest in the APC gene stemmed principally from the findings that the wild-type APC protein is highly expressed in the central nervous system, and upon the finding that it is critically involved in particular syndromes, among which brain tumors play a significant role. Glioblastoma samples were tested for gene instability by PCR/loss of heterozygosity using RFLP method. Two polymorphic markers were used: an Rsa I polymorphic site in exon 11, and an Msp I polymorphic site in exon 15. The results of our analysis for both markers showed allelic loss of the APC gene in 40% of our sample out of 25 heterozygous patients (informativeness 89%). Another 20% of samples demonstrated allelic imbalance of the APC allele in tumor tissue. Altogether, there were 15 samples (60%) demonstrating instability of this tumor suppressor gene. Despite increasing knowledge on glioma biology and genetics, the prognostic tools for glioblastoma still need improvement. Our findings on genomic instability of the APC gene may contribute to better understanding of glioblastoma genetic profile and could be used as a prognostic marker of disease evolution and progression.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Poglavlje u knjizi
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov knjigeGenome Research Advances
Brojčani podacistr. 219-235
ISBN978-1-60021-805-7
URN:NBNurn:nbn:hr:105:120092
Datum objave publikacije2007
ProjektŠifra: 108-1080399-0335
Naziv (hrvatski): Eksperimentalni embrionalni tumori i razvoj zametaka sisavaca in vitro i in vivo
Naziv (engleski): Experimental embryonic tumors and mammalian development in vitro and in vivo
Voditelj: Florijana Jakuš
Pravna nadležnost: Hrvatska
Financijer: MZOS
Linija financiranja: ZP
ProjektŠifra: 108-1081870-1905
Naziv (hrvatski): Uloga signalnog puta wnt u tumorigenezi i embriogenezi mozga
Naziv (engleski): The role of the wnt signaling pathway in brain tumorigenesis and embriogenesis
Voditelj: Nives Pećina-Šlaus
Pravna nadležnost: Hrvatska
Financijer: MZOS
Linija financiranja: ZP
Vrsta resursaTekst
IzdavačNova Science Publishers, Inc.
Prava pristupaOtvoreni pristup
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Datum i vrijeme pohrane2022-04-11 11:42:14