prikaz prve stranice dokumenta Adult Upper Cortical Layer Specific Transcription Factor CUX2 Is Expressed in Transient Subplate and Marginal Zone Neurons of the Developing Human Brain
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Adult Upper Cortical Layer Specific Transcription Factor CUX2 Is Expressed in Transient Subplate and Marginal Zone Neurons of the Developing Human Brain
Cells, 10 (2021), 2; 415. https://doi.org/10.3390/cells10020415
Miškić, Terezija; Kostović, Ivica; Rašin, Mladen-Roko; Krsnik, Željka

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Miškić, T., Kostović, I., Rašin, M. R. i Krsnik, Ž. (2021). Adult Upper Cortical Layer Specific Transcription Factor CUX2 Is Expressed in Transient Subplate and Marginal Zone Neurons of the Developing Human Brain. Cells, 10. (2). doi: 10.3390/cells10020415

Miškić, Terezija, et al. "Adult Upper Cortical Layer Specific Transcription Factor CUX2 Is Expressed in Transient Subplate and Marginal Zone Neurons of the Developing Human Brain." Cells, vol. 10, br. 2, 2021. https://doi.org/10.3390/cells10020415

Miškić, Terezija, Ivica Kostović, Mladen Roko Rašin i Željka Krsnik. "Adult Upper Cortical Layer Specific Transcription Factor CUX2 Is Expressed in Transient Subplate and Marginal Zone Neurons of the Developing Human Brain." Cells 10, br. 2 (2021). https://doi.org/10.3390/cells10020415

Miškić, T., et al. (2021) 'Adult Upper Cortical Layer Specific Transcription Factor CUX2 Is Expressed in Transient Subplate and Marginal Zone Neurons of the Developing Human Brain', Cells, 10(2). doi: 10.3390/cells10020415

Miškić T, Kostović I, Rašin MR, Krsnik Ž. Adult Upper Cortical Layer Specific Transcription Factor CUX2 Is Expressed in Transient Subplate and Marginal Zone Neurons of the Developing Human Brain. Cells [Internet]. 17.02.2021. [pristupljeno 14.04.2024.];10(2). doi: 10.3390/cells10020415

T. Miškić, I. Kostović, M. R. Rašin i Ž. Krsnik, "Adult Upper Cortical Layer Specific Transcription Factor CUX2 Is Expressed in Transient Subplate and Marginal Zone Neurons of the Developing Human Brain", Cells, vol. 10, br. 2, Veljača 2021. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:038706. [Citirano: 14.04.2024.]

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Naslov (engleski)Adult Upper Cortical Layer Specific Transcription Factor CUX2 Is Expressed in Transient Subplate and Marginal Zone Neurons of the Developing Human Brain
AutorTerezija Miškić
AutorIvica Kostović
AutorMladen-Roko Rašin
AutorŽeljka Krsnik
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(HRVATSKI INSTITUT ZA ISTRAŽIVANJE MOZGA)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Neuroznanost
Sažetak (engleski)
Cut-Like Homeobox 2 (Cux2) is a transcription factor involved in dendrite and spine development, and synapse formation of projection neurons placed in mouse upper neocortical layers. Therefore, Cux2 is often used as an upper layer marker in the mouse brain. However, expression of its orthologue CUX2 remains unexplored in the human fetal neocortex. Here, we show that CUX2 protein is expressed in transient compartments of developing neocortical anlage during the main fetal phases of neocortical laminar development in human brain. During the early fetal phase when neurons of the upper cortical layers are still radially migrating to reach their final place in the cortical anlage, CUX2 was expressed in the marginal zone (MZ), deep cortical plate, and pre-subplate. During midgestation, CUX2 was still expressed in the migrating upper cortical neurons as well as in the subplate (SP) and MZ neurons. At the term age, CUX2 was expressed in the gyral white matter along with its expected expression in the upper layer neurons. In sum, CUX2 was expressed in migratory neurons of prospective superficial layers and in the diverse subpopulation of transient postmigratory SP and MZ neurons. Therefore, our findings indicate that CUX2 is a novel marker of distinct transient, but critical histogenetic events during corticogenesis. Given the Cux2 functions reported in animal models, our data further suggest that the expression of CUX2 in postmigratory SP and MZ neurons is associated with their unique dendritic and synaptogenesis characteristics.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaCells
Brojčani podacivol. 10, br. 2, 415
e-ISSN2073-4409
DOIhttps://doi.org/10.3390/cells10020415
URN:NBNurn:nbn:hr:105:038706
Datum objave publikacije2021-02-17
URL dokumentahttps://www.mdpi.com/2073-4409/10/2/415
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2021-06-25 09:09:08